Research Interests: 

 

  • Understanding the role of oxidative stress in viral infections
  • Interaction of ethanol and hepatitis C virus (HCV)
  • Mechanisms of chemical-biological and virus-host interactions to identify novel targets for therapy
  • Mechanism and function of alternate frames decoding during HCV infection

Recent findings from Professor Choi's laboratory suggest that:

  • HCV induces oxidative stress by elevating NAD(P)H oxidase 1 and 4 expression in hepatocytes
  • Redox modulation has significant effects on HCV 
  • Oxidative stress is likely to promote the development of liver diseases, including hepatocellular carcinoma
  • Ethanol, an important cofactor in liver diseases, elevates complete replication of HCV at physiologically relevant doses by elevating NADH/NAD+ ratio and lipid metabolism 
  • F protein (also known as ARFP, Core+1/F, and p17) has important biological functions during HCV infection

Profess Choi has studies in progress to define the underlying mechanisms as well as in vivo relevance of these findings.